Ammonia → HCID 53709462, compound

Participants

Reaction Steps

An excess of NH3 was bubbled into a suspension of 4-(3,5-dichloro-pyridin-4-ylmethyl)-7-methoxy-phthalazin-1-carboxylic acid methyl ester (1.6 g, 4.23 mmoles), prepared as described in example 102, in dry CH3OH, under stirring and dry N2 at 10° C., and the mixture was left for 3 hours at room temperature, then refluxed for 1.5 hours in environment saturated of NH3. After 2 days at room temperature, the mixture was dried to give 1.48 g of the title compound (yield: 67.7%).

Provenance & Evidence