Ammonia → HCID 53709462, compound

HRID 2268908Notes

Reaction equation

HRID 2268908 reaction equation
[NH3:1].C[O:3][C:4]([C:6]1[C:15]2[C:10](=[CH:11][CH:12]=[C:13]([O:16][CH3:17])[CH:14]=2)[C:9]([CH2:18][C:19]2[C:24]([Cl:25])=[CH:23][N:22]=[CH:21][C:20]=2[Cl:26])=[N:8][N:7]=1)=O.N#N>CO>[Cl:25][C:24]1[CH:23]=[N:22][CH:21]=[C:20]([Cl:26])[C:19]=1[CH2:18][C:9]1[C:10]2[C:15](=[CH:14][C:13]([O:16][CH3:17])=[CH:12][CH:11]=2)[C:6]([C:4]([NH2:1])=[O:3])=[N:7][N:8]=1

Participants

5

Reactant 3

HCID 222Ammonia2×HCID 947NitrogenHCID 54227958HCID 54227958, compound

Product 1

HCID 53709462HCID 53709462, compoundYield 67.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

An excess of NH3 was bubbled into a suspension of 4-(3,5-dichloro-pyridin-4-ylmethyl)-7-methoxy-phthalazin-1-carboxylic acid methyl ester (1.6 g, 4.23 mmoles), prepared as described in example 102, in dry CH3OH, under stirring and dry N2 at 10° C., and the mixture was left for 3 hours at room temperature, then refluxed for 1.5 hours in environment saturated of NH3. After 2 days at room temperature, the mixture was dried to give 1.48 g of the title compound (yield: 67.7%).

Workup

  1. customprepared
  2. customthe mixture was dried

Sources & evidence

ORD record
ord-83e9fb5e94f44ee2ac761a41c6ce53d4
Source dataset
uspto-grants-2001_12
Patent number
US06329370B1

Reaction notes

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