反应详情

A suspension of 7-methoxy-4-pyridin-4-ylmethyl-2H-phthalazin-1-one (11.4 g, 42.65 mmoles), prepared as described in example 130, and POCl3 (7.95 ml, 85.30 mmoles) in acetonitrile (110 ml) was refluxed for 1.5 hours. Further POCl3 (40 ml) was added and the reflux was kept on overnight. The mixture was dried, dissolved in water, neutralised with NaHCO3, extracted with CH2Cl2 and dried. The residue was chromatographed (eluent: CH2Cl2/CH3OH 97:3) to give 2.9 g of the title compound (yield: 23.8%).

1. customprepared
2. temperaturewas refluxed for 1.5 hours
3. customThe mixture was dried
4. dissolutiondissolved in water
5. extractionextracted with CH2Cl2
6. customdried
7. customThe residue was chromatographed (eluent: CH2Cl2/CH3OH 97:3)