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HRID2268993

反应详情

EQUATION

反应方程式

HRID 2268993 的结构方程式

REACTANTS

反应物

3
结构：Cc1cc2c(cc1C=O)OCO2
HCID3146242

6-Methyl-2H-1,3-benzodioxole-5-carbaldehyde

C9H8O3

结构：COCCOCN(c1onc(C)c1Cl)S(=O)(=O)c1csc2ncccc12
HCID18614049

未命名化合物

结构：[Li]C(C)(C)C
HCID178418306

未命名化合物

PRODUCTS

生成物

1
结构：COCCOCN(c1onc(C)c1Cl)S(=O)(=O)c1c(C(O)c2cc3c(cc2C)OCO3)sc2ncccc12
HCID18614054

未命名化合物

收率 38%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C1CCOC1
溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

The title compound was prepared by the method of Example 4(B) using N-(4-chloro-3-methyl-5-isoxazolyl)-N-(methoxyethoxy-methyl)thieno[2,3-b]pyridine-3-sulfonamide (0.31 g, 0.75 mmoles)[Example 4(A)], THF (4 ml), t-BuLi (1.7 M, 0.53 ml, 0.90 mmoles) and 2-methyl-4,5-(methylenedioxy)benzaldehyde (0.15 g, 0.90 mmoles). Flash chromatography (40% EtOAc/hexanes) provided 0.16 g (38%) of the title compound.

WORKUP

后处理

  1. customThe title compound was prepared by the method of Example 4(B)