Methanol → HCID 178508674, compound

HRID 2269023Notes

Reaction equation

HRID 2269023 reaction equation
[NH2:1][C:2]1[N:10]=[C:9]([NH:11][CH:12]2[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]2)[N:8]=[C:7]2[C:3]=1[N:4]=[C:5](Br)[N:6]2[CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.C[OH:27]>Cl>[NH2:1][C:2]1[N:10]=[C:9]([NH:11][CH:12]2[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]2)[N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([OH:27])[N:6]2[CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

4

Reactant 2

HCID 887MethanolHCID 18332814HCID 18332814, compound

Product 1

HCID 178508674HCID 178508674, compoundYield 23%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

6-Amino-9-benzyl-8-bromo-2-cyclohexylaminopurine (82 mg, 0.20 mmol) in concentrated hydrochloric acid (30 ml) and methanol (20 ml) were refluxed for 5 hours under heating. After removal of methanol, the reaction mixture was made basic with 28% aqueous ammonia. The resulting crystals were filtered, washed with water and dried to give the subject compound (7 mg, yield 23%).

Workup

  1. temperatureunder heating
  2. customAfter removal of methanol
  3. filtrationThe resulting crystals were filtered
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-e7ca01255aea41198aa973855f4773f2
Source dataset
uspto-grants-2001_12
Patent number
US06329381B1

Reaction notes

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