Ammonia → HCID 178508673, compound

HRID 2269024Notes

Reaction equation

HRID 2269024 reaction equation
[NH2:1][C:2]1[N:10]=[C:9]([NH:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[N:8]=[C:7]2[C:3]=1[N:4]=[C:5](Br)[N:6]2[CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.N.C[OH:28]>Cl>[NH2:1][C:2]1[N:10]=[C:9]([NH:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([OH:28])[N:6]2[CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

5

Reactant 3

HCID 222AmmoniaHCID 887MethanolHCID 18332721HCID 18332721, compound

Product 1

HCID 178508673HCID 178508673, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

6-Amino-2-anilino-9-benzyl-8-bromopurine (80 mg, 0.20 mmol) in concentrated hydrochloric acid (200 ml) and methanol (50 ml) were refluxed for 5 hours under heating. The reaction mixture was condensed in vacuo, 28% aqueous ammonia was added to the residue. The resulting solid was filtered, washed with water and dried to give the subject compound (67 mg yield: quantitatively).

Workup

  1. temperatureunder heating
  2. additionwas added to the residue
  3. filtrationThe resulting solid was filtered
  4. washwashed with water
  5. customdried
  6. customto give the subject compound (67 mg yield

Sources & evidence

ORD record
ord-2cde67a668cd4376aa0b2916ab3bccf7
Source dataset
uspto-grants-2001_12
Patent number
US06329381B1

Reaction notes

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