Ammonia → HCID 178508742, compound

HRID 2269026Notes

Reaction equation

HRID 2269026 reaction equation
[NH2:1][C:2]1[N:10]=[C:9]([NH:11][CH2:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[N:8]=[C:7]2[C:3]=1[N:4]=[C:5](Br)[N:6]2[CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1.N.C[OH:30]>Cl>[NH2:1][C:2]1[N:10]=[C:9]([NH:11][CH2:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([OH:30])[N:6]2[CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

Participants

5

Reactant 3

HCID 222AmmoniaHCID 887MethanolHCID 18332739HCID 18332739, compound

Product 1

HCID 178508742HCID 178508742, compoundYield 77%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

6-Amino-9-benzyl-2-benzylmethylamino-8-bromopurine (85 mg, 0.20 mmol) in concentrated hydrochloric acid (30 ml) and methanol (20 ml) were refluxed for 5 hours under heating. The reaction mixture was made basic with 28% aqueous ammonia, and the resulting crystals were filtered, washed with water and dried to give the subject compound (56 mg, yield 77%).

Workup

  1. temperatureunder heating
  2. filtrationthe resulting crystals were filtered
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-ab6edf85670c4f3d9c2274cdd284e5d6
Source dataset
uspto-grants-2001_12
Patent number
US06329381B1

Reaction notes

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