Ammonia methanol → HCID 178514053, compound

HRID 2269036Notes

Reaction equation

HRID 2269036 reaction equation
[NH3:1].CO.[NH2:4][C:5]1[N:13]=[C:12]([S:14][CH2:15][C:16](OC)=[O:17])[N:11]=[C:10]2[C:6]=1[N:7]=[C:8]([OH:27])[N:9]2[CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>>[NH2:4][C:5]1[N:13]=[C:12]([S:14][CH2:15][C:16]([NH2:1])=[O:17])[N:11]=[C:10]2[C:6]=1[N:7]=[C:8]([OH:27])[N:9]2[CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

Participants

3

Reactant 2

HCID 21705897Ammonia methanolHCID 178501888HCID 178501888, compound

Product 1

HCID 178514053HCID 178514053, compoundYield 89%

Procedure

A 28% ammonia/methanol solution was added to 6-amino-9-benzyl-8-hydroxy-2-(methoxycarbonylmethyl)thiopurine (75 mg, 0.22 mmol). The solution was heated in autoclave for 6 hours and then the solvent was removed in vacuo. To the residue was added methanol and the resulting crystals were filtered to give the subject compound (64 mg, yield 89%).

Workup

  1. temperatureThe solution was heated in autoclave for 6 hours
  2. customthe solvent was removed in vacuo
  3. additionTo the residue was added methanol
  4. filtrationthe resulting crystals were filtered

Sources & evidence

ORD record
ord-5771ec0d9d8a4fe7aa009a0a3a8edc1d
Source dataset
uspto-grants-2001_12
Patent number
US06329381B1

Reaction notes

Loading…