6-Amino-9-benzyl-2-(2-ethoxyethoxy)-8-methoxypurine → HCID 178467997, compound

HRID 2269065Notes

Reaction equation

HRID 2269065 reaction equation
[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][O:14][CH2:15][CH3:16])[N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([O:24]C)[N:6]2[CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>Cl>[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][O:14][CH2:15][CH3:16])[N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([OH:24])[N:6]2[CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

Participants

3

Reactant 1

HCID 183326966-Amino-9-benzyl-2-(2-ethoxyethoxy)-8-methoxypurine

Product 1

HCID 178467997HCID 178467997, compoundYield 84%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

6-Amino-9-benzyl-2-(2-ethoxyethoxy)-8-methoxypurine (110 mg, 0.32 mmol) in concentrated hydrochloric acid (20 ml) was stirred at room temperature for 12 hours. The reaction mixture was evaporated in vacuo to dryness and then 28% aqueous ammonia was added thereto. The resulting crystals were filtered to give the subject compound (88 mg, yield 84%).

Workup

  1. customThe reaction mixture was evaporated in vacuo to dryness
  2. addition28% aqueous ammonia was added
  3. filtrationThe resulting crystals were filtered

Sources & evidence

ORD record
ord-6d7a7f1911c446f5bfbbf3b8857b60ab
Source dataset
uspto-grants-2001_12
Patent number
US06329381B1

Reaction notes

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