Ammonia → HCID 178508986, compound

HRID 2269071Notes

Reaction equation

HRID 2269071 reaction equation
[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][OH:14])[N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([O:22]C)[N:6]2[CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.N>Cl>[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][OH:14])[N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([OH:22])[N:6]2[CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 183327336-Amino-9-benzyl-2-(2-hydroxyethoxy)-8-methoxypurine

Product 1

HCID 178508986HCID 178508986, compoundYield 57.3%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

6-Amino-9-benzyl-2-(2-hydroxyethoxy)-8-methoxypurine (70 mg, 0.22 mmol) in concentrated hydrochloric acid (5 ml) was stirred at room temperature for 5 hours. The reaction mixture was neutralized with 28% aqueous ammonia and the resulting crystals were filtered and washed with water to give the subject compound (38 mg, yield 57%).

Workup

  1. filtrationthe resulting crystals were filtered
  2. washwashed with water

Sources & evidence

ORD record
ord-4183bbf87c3342e88be5724ce7727ef4
Source dataset
uspto-grants-2001_12
Patent number
US06329381B1

Reaction notes

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