反应详情

6-Amino-9-benzyl-2-(3-methylbutyl)thiopurine (260 mg, 0.79 mmol) and bromine (0.5 ml) were dissolved in 100 ml of methylene chloride and the solution was stirred at room temperature for 7 hours. Aqueous sodium thiosulfate was added to the reaction mixture. The organic layer was separated, dried on magnesium sulfate and filtered. The solvent in the filtrate was evaporated in vacuo. The residue was purified with silica gel chromatography (1% methanol/chloroform) to give the subject compound (49 mg, yield 15%).

1. customThe organic layer was separated
2. customdried on magnesium sulfate
3. filtrationfiltered
4. customThe solvent in the filtrate was evaporated in vacuo
5. customThe residue was purified with silica gel chromatography (1% methanol/chloroform)