反应详情

2,6-Diamino-9-benzylpurine (1.00 g, 4.16 mmol) and bromine (1 ml) were dissolved in 100 ml of methylene chloride and the solution was stirred at room temperature for 5 hours. Aqueous sodium thiosulfate was added to the reaction mixture. The organic layer was separated, dried on sodium sulfate and filtered. The solvent in the filtrate was evaporated in vacuo. The residue was purified with silica gel chromatography (1% methanol/chloroform) to give the subject compound (0.62 g, yield 47%).

1. customThe organic layer was separated
2. customdried on sodium sulfate
3. filtrationfiltered
4. customThe solvent in the filtrate was evaporated in vacuo
5. customThe residue was purified with silica gel chromatography (1% methanol/chloroform)