2-Methoxyethylamine → 6-Amino-9-benzyl-2-(2-methoxyethyl)aminopurine

Participants

Reaction Steps

6-Amino-9-benzyl-2-chloropurine (10 mg, 0.385 mmol) and 2-methoxyethylamine in 2 ml of butanol were heated at 120° C. for 9 hours in autoclave. The reaction mixture was concentrated in vacuo to dryness and to the residue was added water. The mixture was extracted with chloroform and the organic layer was dried on sodium sulfate and concentrated in vacuo to dryness. The residue was purified with silica gel chromatography (3% methanol/chloroform) to give the subject compound (83 mg, yield 72%).

Provenance & Evidence