反应详情

6-Amino-9-benzyl-2-chloropurine (10 mg, 0.385 mmol) and 2-methoxyethylamine in 2 ml of butanol were heated at 120° C. for 9 hours in autoclave. The reaction mixture was concentrated in vacuo to dryness and to the residue was added water. The mixture was extracted with chloroform and the organic layer was dried on sodium sulfate and concentrated in vacuo to dryness. The residue was purified with silica gel chromatography (3% methanol/chloroform) to give the subject compound (83 mg, yield 72%).

1. concentrationThe reaction mixture was concentrated in vacuo to dryness and to the residue
2. additionwas added water
3. extractionThe mixture was extracted with chloroform
4. customthe organic layer was dried on sodium sulfate
5. concentrationconcentrated in vacuo to dryness
6. customThe residue was purified with silica gel chromatography (3% methanol/chloroform)