反应详情

To 6-amino-9-benzyl-2-(2-aminoethyl)thiopurine (50 mg, 0.17 mmol) suspended in 2 ml of dichloromethane was added triethylamine (30 ml, 0.2 mmol) and then acetic acid anhydride (20 ml, 0.2 mmol) under ice cooling. After 1 hour the mixture warmed to room temperature. Thereto was added saturated brine. The mixture was extracted with chloroform and the organic layer was dried on magnesium sulfate and concentrated in vacuo to dryness. The residue was purified with silica gel chromatography (1% methanol/chloroform) to give the subject compound (34 mg, yield 66%).

1. extractionThe mixture was extracted with chloroform
2. customthe organic layer was dried on magnesium sulfate
3. concentrationconcentrated in vacuo to dryness
4. customThe residue was purified with silica gel chromatography (1% methanol/chloroform)