反应详情

6-Amino-9-benzyl-2-(2-methoxyethoxy)purine (100 mg, 0.36 mmol) and bromine (0.25 ml) were dissolved in methylene chloride (100 ml). The solution was stirred at room temperature for 6 hours. Aqueous sodium thiosulfate was added to the reaction mixture. The organic layer was separated, dried on sodium sulfate and the solvent was removed in vacuo. The residue was purified with silica gel chromatography (2% methanol/chloroform) to give the subject compound (55 mg, yield 43%).

1. customThe organic layer was separated
2. customdried on sodium sulfate
3. customthe solvent was removed in vacuo
4. customThe residue was purified with silica gel chromatography (2% methanol/chloroform)