反应详情

6-Amino-9-benzyl-2-(2-methoxyethoxy)purine (93 mg, 0.31 mmol) and bromine (1 ml) were dissolved in methylene chloride (100 ml). The solution was stirred at room temperature for 1 hour. Aqueous sodium thiosulfate was added to the reaction mixture. The organic layer was separated, dried on sodium sulfate and concentrated in vacuo to dryness. The residue was purified with silica gel chromatography (1% methanol/chloroform) to give the subject compound (75 mg, yield 64%).

1. customThe organic layer was separated
2. customdried on sodium sulfate
3. concentrationconcentrated in vacuo to dryness
4. customThe residue was purified with silica gel chromatography (1% methanol/chloroform)