Methyl iodide → 1-Bromo-2,4-difluoro-3-methoxybenzene

HRID 2269202Notes

Reaction equation

HRID 2269202 reaction equation
[OH:1][C:2]1[C:3]([F:10])=[C:4]([Br:9])[CH:5]=[CH:6][C:7]=1[F:8].[C:11](=O)([O-])[O-].[K+].[K+].CI>CC(C)=O>[CH3:11][O:1][C:2]1[C:3]([F:10])=[C:4]([Br:9])[CH:5]=[CH:6][C:7]=1[F:8]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 183711103-Bromo-2,6-difluorophenol

Product 1

HCID 183711091-Bromo-2,4-difluoro-3-methoxybenzene

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Conditions

Temperature
20 °C

Procedure

A quantity of 3.7 g of 3-hydroxy-2,4-difluoro-bromobenzene is dissolved in 25 ml of acetone and 2.5 g of potassium carbonate is added followed by 2.2 ml of methyl iodide. The mixture is stirred at 20° C. for 6 hours and the solvent evaporated. After addition of dichloromethane, the suspension is filtered. Evaporation of the solvent affords the desired product.

Workup

  1. customthe solvent evaporated
  2. additionAfter addition of dichloromethane
  3. filtrationthe suspension is filtered
  4. customEvaporation of the solvent

Sources & evidence

ORD record
ord-6d51ffa0023a4bd0adeaeaf9ff6c2a84
Source dataset
uspto-grants-2001_12
Patent number
US06329391B1

Reaction notes

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