HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → 5-Bromo-3-chloro-2,4-difluorobenzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | HCID 12010428 | HCID 12010428 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 5-Bromo-3-chloro-2,4-difluorobenzoyl chloride | HCID 22474757 | — |
Reaction Steps
A quantity of 5.2 g of 5-bromo-3-chloro-2,4-difluorobenzoic acid is suspended in 30 ml of dichloromethane; then 2.92 g of oxalyl chloride is added, and 3 drops of dry DMF are added. The mixture is stirred at room temperature for 3 hours and the desired compound is isolated after evaporation of the solvent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06329391B1 |
| Source dataset | uspto-grants-2001_12 |
| ORD ID | ord-52210b12637c47c18436beba4d1639fe |
| Source note | uspto-grants-2001_12 |