Oxalyl chloride → 5-Bromo-3-chloro-2,4-difluorobenzoyl chloride

HRID 2269206Notes

Reaction equation

HRID 2269206 reaction equation
[Br:1][C:2]1[C:3]([F:13])=[C:4]([Cl:12])[C:5]([F:11])=[C:6]([CH:10]=1)[C:7](O)=[O:8].C(Cl)(=O)C([Cl:17])=O>ClCCl.CN(C=O)C>[Br:1][C:2]1[C:3]([F:13])=[C:4]([Cl:12])[C:5]([F:11])=[C:6]([CH:10]=1)[C:7]([Cl:17])=[O:8]

Participants

5

Reactant 2

HCID 65578Oxalyl chlorideHCID 12010428HCID 12010428, compound

Product 1

HCID 224747575-Bromo-3-chloro-2,4-difluorobenzoyl chloride

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideCatalystHCID 6344DichloromethaneSolvent

Procedure

A quantity of 5.2 g of 5-bromo-3-chloro-2,4-difluorobenzoic acid is suspended in 30 ml of dichloromethane; then 2.92 g of oxalyl chloride is added, and 3 drops of dry DMF are added. The mixture is stirred at room temperature for 3 hours and the desired compound is isolated after evaporation of the solvent.

Sources & evidence

ORD record
ord-52210b12637c47c18436beba4d1639fe
Source dataset
uspto-grants-2001_12
Patent number
US06329391B1

Reaction notes

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