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HRID2269268

反应详情

EQUATION

反应方程式

HRID 2269268 的结构方程式

REACTANTS

反应物

2
结构：CO.Cl
HCID21893726

Hydrochloride methanol

CH5ClO

结构：COc1ccc(C(C)(C)C#CC(F)(F)F)cc1CN[C@H]1CCCN(C(=O)OC(C)(C)C)[C@H]1c1ccccc1
HCID70001735

未命名化合物

PRODUCTS

生成物

1
结构：COc1ccc(C(C)(C)C#CC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1.Cl.Cl
HCID70000615

未命名化合物

收率 75%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCOC(C)=O
溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

To a solution of Compound 59 (34 mg, 0.064 mmol) in AcOEt (8 ml) was added an excess amount of HCl-MeOH. The mixture was stirred for 18 h and then evaporated in vacuo, the residual solid was recrystallized from MeOH-Et2O to give Compound 60 (24 mg, 75%) as a white solid.

WORKUP

后处理

  1. customevaporated in vacuo
  2. customthe residual solid was recrystallized from MeOH-Et2O