(2S, 3S)-3-(5-(1,1-Difluoroethyl)-2-(trifluoromethoxy)benzyl)amino-2-phenylpiperidine → (2S,3S)-3-[(5-Methoxy-1-(trifluoromethyl)indan-6-yl)methylamino]-2-phenylpiperidine

HRID 2269272Notes

Reaction equation

HRID 2269272 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH2:11][C@H:10]([NH:14][CH2:15][C:16]2[CH:24]=[C:23]3[C:19]([CH2:20][CH2:21][CH:22]3[C:25]([F:28])([F:27])[F:26])=[CH:18][C:17]=2[O:29][CH3:30])[C@@H:9]1[C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)=O)(C)(C)C.FC(C1C=CC(OC(F)(F)F)=C(C=1)CN[C@H]1CCCN[C@H]1C1C=CC=CC=1)(F)C>>[CH3:30][O:29][C:17]1[CH:18]=[C:19]2[C:23](=[CH:24][C:16]=1[CH2:15][NH:14][C@H:10]1[CH2:11][CH2:12][CH2:13][NH:8][C@H:9]1[C:31]1[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=1)[CH:22]([C:25]([F:28])([F:26])[F:27])[CH2:21][CH2:20]2

Participants

3

Reactant 2

HCID 57090611(2S, 3S)-3-(5-(1,1-Difluoroethyl)-2-(trifluoromethoxy)benzyl)amino-2-phenylpiperidineHCID 70008982(2S, 3S)-1-tert-Butoxycarbonyl-3-[(5-methoxy-1-(trifluoromethyl)indan-6-yl)methylamino]-2-phenylpiperidine

Product 1

HCID 44593633(2S,3S)-3-[(5-Methoxy-1-(trifluoromethyl)indan-6-yl)methylamino]-2-phenylpiperidine

Procedure

This Compound was prepared from Compound 66 in the same manner of Compound 27.

Sources & evidence

ORD record
ord-f88657638da64eb7ac9fe100e7299e0c
Source dataset
uspto-grants-2001_12
Patent number
US06329396B1

Reaction notes

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