反应详情

Compound 3c was prepared following the procedure described in Step 2 of Example 1 using 400 mg (1.23 mmol) of 2-(5,6-dimethyl-pyridine-3-carbonyl)-3-phenylamino-acrylic acid ethyl ester 2d, and 50 mL of diphenyl ether. The reaction time was 1 h. Purification of the crude product by flash chromatography using 60-100% ethyl acetate in hexane followed by 0-25% methanol in ethyl acetate yielded 201 mg of the product 3c as off-white solid: LC-MSD, m/z for C17H14N2O2 [M+H]+=279.4, HPLC retention time: 0.25 min.

1. customCompound 3c was prepared
2. customPurification of the crude product by flash chromatography