(2S,3S)-3-Amino-1-tert-butoxycarbonyl-2-phenylpiperidine → (2S,3S)-1-tert-Butoxycarbonyl-3-((2,2-difluoro-6-methoxy-1,2,3,4-tetrahydronaphthalen-7-yl)methyl)amino-2-phenylpiperidine

HRID 2269288Notes

Reaction equation

HRID 2269288 reaction equation
N[C@H:2]1CCCN(C(OC(C)(C)C)=O)[C@H:3]1C1C=CC=CC=1.[C:21]([O:25][C:26]([N:28]1[CH2:33][CH2:32][CH2:31][C@H:30]([NH:34][CH2:35][C:36]2[CH:41]=[C:40]([CH:42]([C:47](F)([F:49])[F:48])C(F)(F)F)[CH:39]=[CH:38][C:37]=2[O:51][CH3:52])[C@@H:29]1[C:53]1[CH:58]=[CH:57][CH:56]=[CH:55][CH:54]=1)=[O:27])([CH3:24])([CH3:23])[CH3:22]>>[C:21]([O:25][C:26]([N:28]1[CH2:33][CH2:32][CH2:31][C@H:30]([NH:34][CH2:35][C:36]2[CH:41]=[C:40]3[C:39]([CH2:2][CH2:3][C:47]([F:48])([F:49])[CH2:42]3)=[CH:38][C:37]=2[O:51][CH3:52])[C@@H:29]1[C:53]1[CH:54]=[CH:55][CH:56]=[CH:57][CH:58]=1)=[O:27])([CH3:23])([CH3:24])[CH3:22]

Participants

3

Reactant 2

HCID 11311934(2S,3S)-3-Amino-1-tert-butoxycarbonyl-2-phenylpiperidineHCID 15549735(2S, 3S)-1-tert-Butoxycarbonyl-2-phenyl-3-(5-(2,2,2-trifluoro-1-(trifluoromethyl)ethyl)-2-methoxybenzyl)aminopiperidine

Product 1

HCID 70001230(2S,3S)-1-tert-Butoxycarbonyl-3-((2,2-difluoro-6-methoxy-1,2,3,4-tetrahydronaphthalen-7-yl)methyl)amino-2-phenylpiperidine

Procedure

This compound was prepared from Compound 96 and Compound 12 in the same manner of Compound 13.

Sources & evidence

ORD record
ord-1242df3ac8c443949b04588fd0eb4088
Source dataset
uspto-grants-2001_12
Patent number
US06329396B1

Reaction notes

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