Hydrogen Bromide → 2-Bromo-5-chloro-2,3-dihydro-1H-inden-1-one

HRID 2269292Notes

Reaction equation

HRID 2269292 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[C:7](=[O:11])[CH2:6][CH2:5]2.[Br:12]Br.Br>C(O)(=O)C.O>[Br:12][CH:6]1[CH2:5][C:4]2[C:8](=[CH:9][CH:10]=[C:2]([Cl:1])[CH:3]=2)[C:7]1=[O:11]

Participants

6

Reactant 3

HCID 260Hydrogen BromideHCID 24408BromineHCID 1425995-Chloro-1-indanone

Product 1

HCID 113340692-Bromo-5-chloro-2,3-dihydro-1H-inden-1-one

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 962WaterSolvent

Procedure

5-Chloroindan-1-one is reacted with bromine in glacial acetic acid using a catalytic amount of 48% strength HBr solution in water at room temperature. 2-Bromo-5-chloroindan-1-one is obtained with a melting point of 94-96° C.

Sources & evidence

ORD record
ord-a9e428e4172944a5a0ca5d608df8b27e
Source dataset
uspto-grants-2001_12
Patent number
US06329407B1

Reaction notes

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