Triethylamine → HCID 9794861, compound

HRID 2269294Notes

Reaction equation

HRID 2269294 reaction equation
Br[CH:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:11])[CH:8]=2)[C:3]1=O.[C:13]([CH2:15][C:16]([NH2:18])=[S:17])#[N:14].C(N(CC)CC)C>C(O)C>[Cl:11][C:7]1[CH:6]=[CH:5][C:4]2[C:3]3[N:18]=[C:16]([CH2:15][C:13]#[N:14])[S:17][C:2]=3[CH2:10][C:9]=2[CH:8]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 14162772-CyanoethanethioamideHCID 113340692-Bromo-5-chloro-2,3-dihydro-1H-inden-1-one

Product 1

HCID 9794861HCID 9794861, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1 g (4 mmol) of 2-bromo-5-chloroindan-1-one is stirred with 450 mg (4.5 mmol) of 2-cyanothioacetamide and 0.55 ml (4 mmol) of triethylamine in 10 ml of dry ethanol at room temperature for 4 h. The reaction mixture is concentrated in vacuo, and the residue is purified by chromatography on silica gel with ethyl acetate/n-heptane 1/1. (6-Chloro-8H-indeno[1,2-d]thiazol-2-yl)acetonitrile is obtained with a melting point of 134° C.

Workup

  1. concentrationThe reaction mixture is concentrated in vacuo
  2. customthe residue is purified by chromatography on silica gel with ethyl acetate/n-heptane 1/1

Sources & evidence

ORD record
ord-ef2a10980e844aae823bcd32c757ba93
Source dataset
uspto-grants-2001_12
Patent number
US06329407B1

Reaction notes

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