HCID 53961705, compound → HCID 18179531, compound

HRID 2269323Notes

Reaction equation

HRID 2269323 reaction equation
C([O:5][C:6]([CH:8]1[C:13]([OH:15])([CH3:14])[CH2:12][CH2:11][CH2:10][N:9]1[S:16]([C:19]1[CH:24]=[CH:23][C:22]([O:25][CH2:26][C:27]2[CH:32]=[CH:31][C:30]([F:33])=[CH:29][CH:28]=2)=[CH:21][CH:20]=1)(=[O:18])=[O:17])=[O:7])(C)(C)C>FC(F)(F)C(O)=O.C(Cl)Cl>[F:33][C:30]1[CH:29]=[CH:28][C:27]([CH2:26][O:25][C:22]2[CH:21]=[CH:20][C:19]([S:16]([N:9]3[CH2:10][CH2:11][CH2:12][C:13]([OH:15])([CH3:14])[CH:8]3[C:6]([OH:7])=[O:5])(=[O:17])=[O:18])=[CH:24][CH:23]=2)=[CH:32][CH:31]=1

Participants

3

Reactant 1

HCID 53961705HCID 53961705, compound

Product 1

HCID 18179531HCID 18179531, compound

Reagents, catalysts & solvents 1

HCID 21863450Trifluoroacetic acid methylene chlorideSolvent

Procedure

A solution of 1-[4-(4-fluoro-benzyloxy)-benzenesulfonyl]-3-hydroxy-3-methyl-piperidine-2-carboxylic acid tert-butyl ester in 2 mL of 1:1 trifluoroacetic acid-CH2Cl2 was stirred for 15 min-2 h at room temperature. Concentration in vacuo afforded 1-[4-(4-fluoro-benzyloxy)-benzenesulfonyl]-3-hydroxy-3-methyl-piperidine-2-carboxylic acid as a colorless syrup:

Workup

  1. concentrationConcentration in vacuo

Sources & evidence

ORD record
ord-2086a5cabf4f4f6eb1f5555c90d67187
Source dataset
uspto-grants-2001_12
Patent number
US06329397B1

Reaction notes

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