Hydrochloric Acid → HCID 70212260, compound

HRID 2269345Notes

Reaction equation

HRID 2269345 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([NH:7][C:8](=[O:22])[C@@H:9]([NH:14]C(OC(C)(C)C)=O)[C:10]([CH3:13])([CH3:12])[CH3:11])[CH:2]=1.[ClH:23]>ClCCl.O1CCOCC1>[ClH:23].[ClH:23].[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([NH:7][C:8](=[O:22])[C@@H:9]([NH2:14])[C:10]([CH3:11])([CH3:12])[CH3:13])[CH:2]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 70212244HCID 70212244, compound

Product 1

HCID 70212260HCID 70212260, compoundYield 94%

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Conditions

Temperature
25 °C

Procedure

To a solution of (2S)-2-tert-butoxycarbonylamino-3,3-dimethylbutanoic acid 3-pyridylamide (1.6 g, 5.21 mmol) in dichloromethane (10 mL) cooled at 0° C. is added 4 M HCl in dioxane (10 mL). The resulting solution is allowed to warm to 25° C. and is stirred for 3 h. The reaction mixture is concentrated and the solid is filtered to provide (2S)-2-amino-3,3-dimethylbutanoic acid 3-pyridylamide dihydrochloride (1.40 g, 94% yield) as a white solid.

Workup

  1. concentrationThe reaction mixture is concentrated
  2. filtrationthe solid is filtered

Sources & evidence

ORD record
ord-a10bcdccca694dd88a9f6a3686a9bccc
Source dataset
uspto-grants-2001_12
Patent number
US06329400B1

Reaction notes

Loading…