Ammonia → HCID 18334087, compound

HRID 2269374Notes

Reaction equation

HRID 2269374 reaction equation
C[O:2][C:3]1[C:4](=[O:34])[C:5](=O)[C:6]=1[NH:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([CH:14]([C:25]2[CH:30]=[CH:29][C:28]([O:31][CH3:32])=[CH:27][CH:26]=2)[NH:15][CH2:16][CH2:17][CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH:9]=1.[NH3:35]>C(O)C>[NH2:35][C:5]1[C:4](=[O:34])[C:3](=[O:2])[C:6]=1[NH:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([CH:14]([C:25]2[CH:26]=[CH:27][C:28]([O:31][CH3:32])=[CH:29][CH:30]=2)[NH:15][CH2:16][CH2:17][CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH:9]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 18334093HCID 18334093, compound

Product 1

HCID 18334087HCID 18334087, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In a similar manner to that described in Example (1d), 3-methoxy-4-{3-[(4-methoxyphenyl)-(3-phenylpropylamino)methyl]phenylamino}-3-cyclobutene-1,2-dione [prepared as described in step (c) above] and a solution of ammonia in ethanol (2N, 8 ml) were reacted, to afford the title compound (1.58 g) as a yellow solid.

Sources & evidence

ORD record
ord-fa66e8e95269474b9f66c2796f99d91e
Source dataset
uspto-grants-2001_12
Patent number
US06329405B1

Reaction notes

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