Sodium borohydride → HCID 18347047, compound

HRID 2269387Notes

Reaction equation

HRID 2269387 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([C:21]2[CH:26]=[CH:25][CH:24]=[C:23]([N+:27]([O-])=O)[CH:22]=2)[NH:10][CH:11]([C:13]2[CH:18]=[C:17]([F:19])[CH:16]=[C:15]([F:20])[CH:14]=2)[CH3:12])=[CH:5][CH:4]=1.[BH4-].[Na+]>CO.O.O.O.O.O.O.[Ni](Cl)Cl>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([NH:10][CH:11]([C:13]2[CH:14]=[C:15]([F:20])[CH:16]=[C:17]([F:19])[CH:18]=2)[CH3:12])[C:21]2[CH:22]=[C:23]([NH2:27])[CH:24]=[CH:25][CH:26]=2)=[CH:5][CH:4]=1

Participants

5

Reactant 2

HCID 4311764Sodium borohydrideHCID 18334109N-[(4-methoxyphenyl)-(3-nitrophenyl)methyl]-N-[1-(3,5-difluorophenyl)ethyl]amine

Product 1

HCID 18347047HCID 18347047, compoundYield 91.4%

Reagents, catalysts & solvents 2

HCID 11791229Dichloronickel;hexahydrateCatalystHCID 887MethanolSolvent

Procedure

In a similar manner to that described in Example (1b), a solution of N-[(4-methoxyphenyl)-(3-nitrophenyl)methyl]-N-[1-(3,5-difluorophenyl)ethyl]amine (2.65 g) [prepared as described in step (a) above] in methanol (50 ml), nickel chloride hexahydrate (3.16 g) and sodium borohydride (1.0 g) were reacted, to afford the title compound (2.24 g) as a pale orange oil.

Sources & evidence

ORD record
ord-b7e6b9b60ce64dbea5b2e48a637acf34
Source dataset
uspto-grants-2001_12
Patent number
US06329405B1

Reaction notes

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