Sodium borohydride → HCID 18347070, compound

HRID 2269388Notes

Reaction equation

HRID 2269388 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([N+:24]([O-])=O)[CH:19]=2)[NH:10][CH:11]([C:13]2[S:14][CH:15]=[CH:16][CH:17]=2)[CH3:12])=[CH:5][CH:4]=1.[BH4-].[Na+]>C(O)C.O.O.O.O.O.O.[Ni](Cl)Cl>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([NH:10][CH:11]([C:13]2[S:14][CH:15]=[CH:16][CH:17]=2)[CH3:12])[C:18]2[CH:19]=[C:20]([NH2:24])[CH:21]=[CH:22][CH:23]=2)=[CH:5][CH:4]=1

Participants

5

Reactant 2

HCID 4311764Sodium borohydrideHCID 18334177HCID 18334177, compound

Product 1

HCID 18347070HCID 18347070, compoundYield 85.6%

Reagents, catalysts & solvents 2

HCID 11791229Dichloronickel;hexahydrateCatalystHCID 702EthanolSolvent

Procedure

In a similar manner to that described in Example (1b), a solution of N-[(4-methoxyphenyl)-(3-nitrophenyl)methyl]-N-[1-(2-thienyl)ethyl]amine (2.11 g) [prepared as described in step (a) above] in ethanol (40 ml), nickel chloride hexahydrate (2.71 g) and sodium borohydride (863 mg) were reacted, to afford the title compound (1.66 g) as a dark brown oil.

Sources & evidence

ORD record
ord-8fb7296a40a947b89f4929f94a5ac5a0
Source dataset
uspto-grants-2001_12
Patent number
US06329405B1

Reaction notes

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