Sodium borohydride → HCID 70189155, compound

HRID 2269394Notes

Reaction equation

HRID 2269394 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([C:19]2[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=2)[NH:10][C@H:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH3:12])=[CH:5][C:4]=1[N+:26]([O-])=O.[BH4-].[Na+]>O.O.O.O.O.O.[Ni](Cl)Cl>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([C:19]2[CH:20]=[CH:21][C:22]([F:25])=[CH:23][CH:24]=2)[NH:10][C@H:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH3:12])=[CH:5][C:4]=1[NH2:26]

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 70189173HCID 70189173, compound

Product 1

HCID 70189155HCID 70189155, compoundYield 94.6%

Reagents, catalysts & solvents 1

HCID 11791229Dichloronickel;hexahydrateCatalyst

Procedure

In a similar manner to that described in Example (1b), isomer A of N-[(4-methoxy-3-nitrophenyl)-(4-fluorophenyl)methyl]-N-[(S)-1-phenylethyl]amine (670 mg) [prepared as described in step (a) above], nickel chloride hexahydrate (856 mg) and sodium borohydride (272 mg) were reacted, to afford isomer A (584 mg) of the title compound as a yellow oil.

Sources & evidence

ORD record
ord-c7ae2f13fc844e33a87495d87719e21f
Source dataset
uspto-grants-2001_12
Patent number
US06329405B1

Reaction notes

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