Sodium borohydride → HCID 70189156, compound

HRID 2269396Notes

Reaction equation

HRID 2269396 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:14]([C:24]2[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=2)[NH:15][C@H:16]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH3:17])[CH:6]=[C:7]([N+:11]([O-])=O)[C:8]=1[O:9][CH3:10].[BH4-].[Na+]>O.O.O.O.O.O.[Ni](Cl)Cl>[CH3:10][O:9][C:8]1[C:3]([O:2][CH3:1])=[CH:4][C:5]([CH:14]([C:24]2[CH:25]=[CH:26][C:27]([F:30])=[CH:28][CH:29]=2)[NH:15][C@H:16]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH3:17])=[CH:6][C:7]=1[NH2:11]

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 70189217HCID 70189217, compound

Product 1

HCID 70189156HCID 70189156, compound

Reagents, catalysts & solvents 1

HCID 11791229Dichloronickel;hexahydrateCatalyst

Procedure

In a similar manner to that described in Example (15b), N-[(3,4-dimethoxy-5-nitrophenyl)-(4-fluorophenyl)methyl]-N-[(S)-1-phenylethyl]amine (2.73 g) [prepared as described in step (a) above], nickel chloride hexahydrate (3.19 g) and sodium borohydride (1.01 g) were reacted, and the reaction mixture was purified, to afford isomer A (895 mg) as a yellow oil and isomer B (319 mg) as a pale yellow oil of the title compound.

Workup

  1. customwere reacted
  2. customthe reaction mixture was purified

Sources & evidence

ORD record
ord-829ef1375e744843868735bf38444c23
Source dataset
uspto-grants-2001_12
Patent number
US06329405B1

Reaction notes

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