Sodium borohydride → HCID 70188165, compound

HRID 2269399Notes

Reaction equation

HRID 2269399 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([CH:10]([C:21]2[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[CH:23][CH:22]=2)[NH:11][C@H:12]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([F:20])[CH:15]=2)[CH3:13])[CH:7]=[CH:8][CH:9]=1)([O-])=O.[BH4-].[Na+]>CO.O.O.O.O.O.O.[Ni](Cl)Cl>[CH3:28][O:27][C:24]1[CH:25]=[CH:26][C:21]([CH:10]([NH:11][C@H:12]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([F:20])[CH:15]=2)[CH3:13])[C:6]2[CH:5]=[C:4]([NH2:1])[CH:9]=[CH:8][CH:7]=2)=[CH:22][CH:23]=1

Participants

5

Reactant 2

HCID 4311764Sodium borohydrideHCID 70188106HCID 70188106, compound

Product 1

HCID 70188165HCID 70188165, compoundYield 93.3%

Reagents, catalysts & solvents 2

HCID 11791229Dichloronickel;hexahydrateCatalystHCID 887MethanolSolvent

Procedure

In a similar manner to that described in Example (1b), a solution N-[(3-nitrophenyl)-(4-methoxyphenyl)methyl]-N-[(S)-1-(3-fluorophenyl)ethyl)amine (2.70 g) [prepared as described in step (a) above] in methanol (100 ml), nickel chloride hexahydrate (3.37 g) and sodium borohydride (1.13 g) were reacted, to afford the title compound (2.32 g) as a yellow oil.

Sources & evidence

ORD record
ord-b1a049dc711d43989b5c88a721f0667e
Source dataset
uspto-grants-2001_12
Patent number
US06329405B1

Reaction notes

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