Sodium borohydride → HCID 70189225, compound

HRID 2269401Notes

Reaction equation

HRID 2269401 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([CH:10]([C:20]2[CH:25]=[CH:24][N:23]=[CH:22][CH:21]=2)[NH:11][C@H:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH3:13])[CH:7]=[CH:8][CH:9]=1)([O-])=O.[BH4-].[Na+]>O.O.O.O.O.O.[Ni](Cl)Cl>[C:14]1([C@@H:12]([NH:11][CH:10]([C:20]2[CH:25]=[CH:24][N:23]=[CH:22][CH:21]=2)[C:6]2[CH:5]=[C:4]([NH2:1])[CH:9]=[CH:8][CH:7]=2)[CH3:13])[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 70188147HCID 70188147, compound

Product 1

HCID 70189225HCID 70189225, compoundYield 74.8%

Reagents, catalysts & solvents 1

HCID 11791229Dichloronickel;hexahydrateCatalyst

Procedure

In a similar manner to that described in Example (1b), isomer B of N-[(3-nitrophenyl)-4-pyridylmethyl]-[(S)-1-phenylethyl]amine (1.02 g), nickel chloride hexahydrate (1.47 g) and sodium borohydride (470 mg) were reacted, to afford isomer B of the title compound (694 mg) as a pale yellow oil.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-ebe7cd1acf7843e7b0e9102d5e070473
Source dataset
uspto-grants-2001_12
Patent number
US06329405B1

Reaction notes

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