HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → N-[(3-Nitrophenyl)-(4-fluorophenyl)methyl]-N-[1-(3,4-difluorophenyl)ethyl]amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | 4-Fluoro-3'-nitrobenzophenone | HCID 10490558 | — |
| Reactant | Benzenemethanamine, 3,4-difluoro-α-methyl-, hydrochloride (1:1) | HCID 18347113 | — |
| Catalyst | Titanium Tetrachloride | HCID 24193 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | N-[(3-Nitrophenyl)-(4-fluorophenyl)methyl]-N-[1-(3,4-difluorophenyl)ethyl]amine | HCID 18334151 | 96.1% |
Reaction Steps
In a similar manner to that described in Example (1a), 4-fluoro-3′-nitrobenzophenone (2.0 g), 1-(3,4-difluorophenyl)ethylamine hydrochloride (3.16 g), triethylamine (6.82 ml), titanium tetrachloride (1.08 ml), sodium cyanoborohydride (2.28 g) and acetic acid (0.7 ml) were reacted, to afford the title compound (3.03 g) as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06329405B1 |
| Source dataset | uspto-grants-2001_12 |
| ORD ID | ord-53fc852bbba2495287c85e1e8c4d1ed3 |
| Source note | uspto-grants-2001_12 |