HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium borohydride → 3-{Cyclohexyl-[1-(3,4-difluorophenyl)ethylamino]methyl}phenylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | Benzenemethanamine, 3,4-difluoro-α-methyl-, hydrochloride (1:1) | HCID 18347113 | — |
| Reactant | HCID 88201955 | HCID 88201955 | — |
| Catalyst | Titanium Tetrachloride | HCID 24193 | — |
| Catalyst | Dichloronickel;hexahydrate | HCID 11791229 | — |
| Product | 3-{Cyclohexyl-[1-(3,4-difluorophenyl)ethylamino]methyl}phenylamine | HCID 18334085 | 67.2% |
Reaction Steps
In a similar manner to that described in Example (25a), cyclohexyl-3-nitrophenylketone (3.0 g), 1-(3,4-difluorophenyl)ethylamine hydrochloride (4.98 g) triethylamine (10.8 ml), titanium tetrachloride (1.70 ml), nickel chloride hexahydrate (6.11 g), and sodium borohydride (2.05 g) were reacted, to afford the title compound (1.59 g) as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06329405B1 |
| Source dataset | uspto-grants-2001_12 |
| ORD ID | ord-86a73003309c49208cc8e9076de99398 |
| Source note | uspto-grants-2001_12 |