3-Cyclobutene-1,2-dione, 3,4-dimethoxy- → HCID 18334249, compound

HRID 2269429Notes

Reaction equation

HRID 2269429 reaction equation
Cl.[NH2:2][C:3]1[CH:4]=[C:5]([CH:9]([C:21]2[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[CH:23][CH:22]=2)[NH:10][C:11](=[O:20])[CH:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH3:13])[CH:6]=[CH:7][CH:8]=1.[CH3:29][O:30][C:31]1[C:32](=O)[C:33](=[O:37])[C:34]=1[O:35]C>>[CH3:29][O:30][C:31]1[C:34](=[O:35])[C:33](=[O:37])[C:32]=1[NH:2][C:3]1[CH:4]=[C:5]([CH:9]([C:21]2[CH:22]=[CH:23][C:24]([O:27][CH3:28])=[CH:25][CH:26]=2)[NH:10][C:11](=[O:20])[CH:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH3:13])[CH:6]=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 1232273-Cyclobutene-1,2-dione, 3,4-dimethoxy-HCID 18334172HCID 18334172, compound

Product 1

HCID 18334249HCID 18334249, compoundYield 64.6%

Procedure

In a similar manner to that described in Example (46e) N-[(3-aminophenyl)-(4-methoxyphenyl)methyl]-2-phenylpropionamide hydrochloride (555 mg) [prepared as described in step (b) above] and 3,4-dimethoxy-3-cyclobutene-1,2-dione (398 mg) were reacted, to afford the title compound (425 mg) as a yellow solid.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-9d33bb34a1e74220a7ff25c488763cd4
Source dataset
uspto-grants-2001_12
Patent number
US06329405B1

Reaction notes

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