Sodium borohydride → HCID 18334157, compound

HRID 2269431Notes

Reaction equation

HRID 2269431 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([NH:19][CH2:20][CH:21]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[OH:22])[C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([N+:16]([O-])=O)[CH:11]=2)=[CH:5][CH:4]=1.[BH4-].[Na+]>CO.O.O.O.O.O.O.[Ni](Cl)Cl>[NH2:16][C:12]1[CH:11]=[C:10]([CH:9]([NH:19][CH2:20][CH:21]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[OH:22])[C:6]2[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=2)[CH:15]=[CH:14][CH:13]=1

Participants

5

Reactant 2

HCID 4311764Sodium borohydrideHCID 18334185HCID 18334185, compound

Product 1

HCID 18334157HCID 18334157, compoundYield 73.3%

Reagents, catalysts & solvents 2

HCID 11791229Dichloronickel;hexahydrateCatalystHCID 887MethanolSolvent

Procedure

In a similar manner to that described in Example (1b), a solution of 2-{[(4-methoxyphenyl)-(3-nitrophenyl)methyl]amino}-1-phenylethanol (3.26 g) [prepared as described in step (b) above] in methanol (60 m), nickel chloride hexahydrate (4.09 g) and sodium borohydride (1.3 g) were reacted, to afford the title compound (2.2 g) as a yellow oil.

Sources & evidence

ORD record
ord-44fb64fd108d466884b7a62e4c6cce4d
Source dataset
uspto-grants-2001_12
Patent number
US06329405B1

Reaction notes

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