Ammonia → HCID 18347088, compound

HRID 2269437Notes

Reaction equation

HRID 2269437 reaction equation
C[O:2][C:3]1[C:4](=[O:33])[C:5](=O)[C:6]=1[NH:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([CH:14]([C:24]2[CH:29]=[CH:28][C:27]([O:30][CH3:31])=[CH:26][CH:25]=2)[NH:15][CH2:16][CH2:17][CH:18]2[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]2)[CH:9]=1.[NH3:34]>C(O)C>[NH2:34][C:5]1[C:4](=[O:33])[C:3](=[O:2])[C:6]=1[NH:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([CH:14]([C:24]2[CH:25]=[CH:26][C:27]([O:30][CH3:31])=[CH:28][CH:29]=2)[NH:15][CH2:16][CH2:17][CH:18]2[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]2)[CH:9]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 18347118HCID 18347118, compound

Product 1

HCID 18347088HCID 18347088, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In a similar manner to that described in Example (1d), 3-methoxy-4-{3-[(4-methoxyphenyl)-(2-cyclohexylethylamino)methyl]phenylamino}-3-cyclobutene-1,2-dione (630 mg) [prepared as described in step (c) above] and a solution of ammonia in ethanol (2N, 2.8 ml) were reacted, to give the title compound (536 mg) as a yellow solid.

Sources & evidence

ORD record
ord-70e4fef387ce4fb4b7692f32697139f1
Source dataset
uspto-grants-2001_12
Patent number
US06329405B1

Reaction notes

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