Sodium borohydride → 5-{[1-(3,5-Difluorophenyl)ethylamino]-(4-methoxyphenyl)methyl}-2,3-dimethoxyphenylamine

Participants

Reaction Steps

Following a similar procedure to that described in Example (1b), 870 mg of N-[1-(3,5-difluorophenyl)ethyl-N-[(3,4-dimethoxy-5-nitrophenyl)-(4-methoxyphenyl)methyl]amine [prepared as described in step (a) above], 1.04 g of nickel chloride hexahydrate and 302 mg of sodium borohydride were reacted, to obtain 550 mg of the title compound as a colorless oil.

Provenance & Evidence