HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium borohydride → 3-{[(R)-1-(3,5-Difluorophenyl)ethylamino]-(4-methoxyphenyl)methyl}phenylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | N-[(R)-1-(3,5-Difluorophenyl)ethyl]-N-[(4-methoxyphenyl)-(3-nitrophenyl)methyl]amine | HCID 70189169 | — |
| Catalyst | Dichloronickel;hexahydrate | HCID 11791229 | — |
| Product | 3-{[(R)-1-(3,5-Difluorophenyl)ethylamino]-(4-methoxyphenyl)methyl}phenylamine | HCID 70189305 | — |
Reaction Steps
Following a similar procedure to that described in Example (1b), 820 mg of isomer B of N-[(R)-1-(3,5-difluorophenyl)ethyl]-N-[(4-methoxyphenyl)-(3-nitrophenyl)methyl]amine [prepared as described in step (a) above], 1.13 g of nickel chloride hexahydrate and 328 mg of sodium borohydride were reacted, to obtain 480 mg of isomer B of the title compound as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06329405B1 |
| Source dataset | uspto-grants-2001_12 |
| ORD ID | ord-2748c1b6f1624c2aa0aabcabf106edd7 |
| Source note | uspto-grants-2001_12 |