Sodium borohydride → 3-{[(R)-1-(3,5-Difluorophenyl)ethylamino]-(4-fluorophenyl)methyl}phenylamine

Participants

Reaction Steps

Following a reaction and purification procedure similar to those described in Example (59b), 4.40 g of N-[(R)-1-(3,5-difluorophenyl)ethyl]-N-[(4-fluorophenyl)-(3-nitrophenyl)methyl]amine [prepared as described in step (a) above], 6.54 g of nickel chloride hexahydrate and 1.81 g of sodium borohydride were reacted, to obtain 1.24 g of isomer A and 1.66 g of isomer B of the title compound as yellow oils, respectively.

Provenance & Evidence