Sodium borohydride → HCID 70188103, compound

HRID 2269458Notes

Reaction equation

HRID 2269458 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([N+:25]([O-])=O)[CH:20]=2)[NH:9][C@@H:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH2:11][CH3:12])=[CH:4][CH:3]=1.[BH4-].[Na+]>O.O.O.O.O.O.[Ni](Cl)Cl>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([NH:9][C@@H:10]([C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH2:11][CH3:12])[C:19]2[CH:20]=[C:21]([NH2:25])[CH:22]=[CH:23][CH:24]=2)=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 70189747HCID 70189747, compound

Product 1

HCID 70188103HCID 70188103, compound

Reagents, catalysts & solvents 1

HCID 11791229Dichloronickel;hexahydrateCatalyst

Procedure

Following a reaction and purification procedure similar to those described in Example (59b), 2.70 g of N-[(4-fluorophenyl)-(3-nitrophenyl)methyl]-N-[(R)-1-phenylpropyl]amine [prepared as described in step (a) above], 4.06 g of nickel chloride hexahydrate and 1.18 g of sodium borohydride were reacted, to obtain 778 mg of isomer A and 615 mg of isomer B of the title compound as yellow oils, respectively.

Workup

  1. customa reaction and purification procedure similar to
  2. customwere reacted

Sources & evidence

ORD record
ord-47009814611e40a4b79d7f6480ff141a
Source dataset
uspto-grants-2001_12
Patent number
US06329405B1

Reaction notes

Loading…