HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → N-[1-(3,4-Difluorophenyl)ethyl]-N-[(4-fluoro-3-nitrophenyl)-(4-methoxyphenyl)methyl}amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | 4-Fluoro-3-nitrophenyl 4-methoxyphenyl ketone | HCID 18334274 | — |
| Reactant | Benzenemethanamine, 3,4-difluoro-α-methyl-, hydrochloride (1:1) | HCID 18347113 | — |
| Catalyst | Titanium Tetrachloride | HCID 24193 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | N-[1-(3,4-Difluorophenyl)ethyl]-N-[(4-fluoro-3-nitrophenyl)-(4-methoxyphenyl)methyl}amine | HCID 18347053 | 86.9% |
Reaction Steps
Following a similar procedure to that described in Example (1a), 2.0 g of 4-fluoro-3-nitrophenyl 4-methoxyphenyl ketone, 2.81 g of 1-(3,4-difluorophenyl)ethylamine hydrochloride, 6.08 ml of triethylamine, 0.96 ml of titanium tetrachloride, 2.03 g of sodium cyanoborohydride and 0.62 ml of acetic acid were reacted, to obtain 2.63 g of the title compound as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06329405B1 |
| Source dataset | uspto-grants-2001_12 |
| ORD ID | ord-659fbc404ecb4b0c800e3c561479bd55 |
| Source note | uspto-grants-2001_12 |