HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium borohydride → 5-{[1-(3,4-Difluorophenyl)ethylamino]-(4-methoxyphenyl)methyl}-2-fluorophenylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | N-[1-(3,4-Difluorophenyl)ethyl]-N-[(4-fluoro-3-nitrophenyl)-(4-methoxyphenyl)methyl}amine | HCID 18347053 | — |
| Catalyst | Dichloronickel;hexahydrate | HCID 11791229 | — |
| Product | 5-{[1-(3,4-Difluorophenyl)ethylamino]-(4-methoxyphenyl)methyl}-2-fluorophenylamine | HCID 18334266 | 78.4% |
Reaction Steps
Following a similar procedure to that described in Example (1b), 2.5 g of N-[1-(3,4-difluorophenyl)ethyl]-N-[(4-fluoro-3-nitrophenyl)-(4-methoxyphenyl)methyl]amine [prepared as described in step (a) above], 3.29 g of nickel chloride hexahydrate and 957 mg of sodium borohydride were reacted, to obtain 1.82 g of the title compound as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06329405B1 |
| Source dataset | uspto-grants-2001_12 |
| ORD ID | ord-efae7676064a4463b814951adfd33435 |
| Source note | uspto-grants-2001_12 |