Sodium borohydride → 3-{[1-(3,4-Difluorophenyl)ethylamino]-(4-methoxyphenyl)methyl}-4-fluorophenylamine

Participants

Role	Name	HCID	Charge
Reactant	Sodium borohydride	HCID 4311764	—
Reactant	N-[1-(3,4-Difluorophenyl)ethyl]-N-[(2-fluoro-5-nitrophenyl)-(4-methoxyphenyl)methyl]amine	HCID 18334198	—
Catalyst	Dichloronickel;hexahydrate	HCID 11791229	—
Product	3-{[1-(3,4-Difluorophenyl)ethylamino]-(4-methoxyphenyl)methyl}-4-fluorophenylamine	HCID 18334105	—

Reaction Steps

Following a reaction and purification procedure similar to those described in Example (59b), 800 mg of N-[1-(3,4-difluorophenyl)ethyl]-N-[(2-fluoro-5-nitrophenyl)-(4-methoxyphenyl)methyl]amine [prepared as described in step (a) above], 1.05 g of nickel chloride hexahydrate and 306 mg of sodium borohydride were reacted, to obtain 330 mg of isomer A and 350 mg of isomer B of the title compound as yellow oils, respectively.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06329405B1
Source dataset	uspto-grants-2001_12
ORD ID	ord-c5e1fec2f99c481ba2d98339cbfc1a38
Source note	uspto-grants-2001_12