Sodium borohydride → HCID 18334235, compound

HRID 2269465Notes

Reaction equation

HRID 2269465 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[CH:9]([NH:11][CH:12]([C:22]1[CH:27]=[CH:26][C:25]([O:28][CH3:29])=[CH:24][CH:23]=1)[C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([N+:19]([O-])=O)[CH:14]=1)[CH3:10].[BH4-].[Na+]>O.O.O.O.O.O.[Ni](Cl)Cl>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[CH:9]([NH:11][CH:12]([C:22]1[CH:23]=[CH:24][C:25]([O:28][CH3:29])=[CH:26][CH:27]=1)[C:13]1[CH:14]=[C:15]([NH2:19])[CH:16]=[CH:17][CH:18]=1)[CH3:10]

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 18347134HCID 18347134, compound

Product 1

HCID 18334235HCID 18334235, compoundYield 86.1%

Reagents, catalysts & solvents 1

HCID 11791229Dichloronickel;hexahydrateCatalyst

Procedure

Following a similar procedure to that described in Example (1b), 2.80 g of N-[1-(2,4-difluorophenyl)ethyl]-N-[(4-methoxyphenyl)-(3-nitrophenyl)methyl]amine [prepared as described in step (a) above], 3.34 g of nickel chloride hexahydrate and 1.12 g of sodium borohydride were reacted, to obtain 2.23 g of the title compound as a yellow oil.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-734ebd98f70f48b598e85d838e61e749
Source dataset
uspto-grants-2001_12
Patent number
US06329405B1

Reaction notes

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