Sodium borohydride → HCID 18334178, compound

HRID 2269469Notes

Reaction equation

HRID 2269469 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([N+:23]([O-])=O)[CH:18]=2)[NH:9][CH:10]([C:12]2[S:13][CH:14]=[CH:15][CH:16]=2)[CH3:11])=[CH:4][CH:3]=1.[BH4-].[Na+]>O.O.O.O.O.O.[Ni](Cl)Cl>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([NH:9][CH:10]([C:12]2[S:13][CH:14]=[CH:15][CH:16]=2)[CH3:11])[C:17]2[CH:18]=[C:19]([NH2:23])[CH:20]=[CH:21][CH:22]=2)=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 18334192HCID 18334192, compound

Product 1

HCID 18334178HCID 18334178, compound

Reagents, catalysts & solvents 1

HCID 11791229Dichloronickel;hexahydrateCatalyst

Procedure

Following a similar reaction, separation and purification procedure to that described in Example (59b), 2.41 of N-[(4-fluorophenyl)-(3-nitrophenyl)methyl]-N-[1-(thiophen-2-yl)ethyl]amine [prepared as described in step (a) above], 3.22 g of nickel chloride hexahydrate and 1.03 g of sodium borohydride were reacted, to obtain 687 mg of isomer A and 552 mg of isomer B of the title compound as pale yellow oils, respectively.

Workup

  1. customa similar reaction, separation and purification procedure to
  2. customwere reacted

Sources & evidence

ORD record
ord-88c472f48b4741aea7f423842d0ab01d
Source dataset
uspto-grants-2001_12
Patent number
US06329405B1

Reaction notes

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