Sodium borohydride → HCID 18347089, compound

HRID 2269470Notes

Reaction equation

HRID 2269470 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:11]([NH:13][CH:14]([C:24]2[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=2)[C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([N+:21]([O-])=O)[CH:16]=2)[CH3:12])[CH:6]=[C:7]([O:9][CH3:10])[CH:8]=1.[BH4-].[Na+]>O.O.O.O.O.O.[Ni](Cl)Cl>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:11]([NH:13][CH:14]([C:24]2[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=2)[C:15]2[CH:16]=[C:17]([NH2:21])[CH:18]=[CH:19][CH:20]=2)[CH3:12])[CH:6]=[C:7]([O:9][CH3:10])[CH:8]=1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 18334078HCID 18334078, compound

Product 1

HCID 18347089HCID 18347089, compound

Reagents, catalysts & solvents 1

HCID 11791229Dichloronickel;hexahydrateCatalyst

Procedure

Following a similar reaction, separation and purification procedure to that described in Example (59b), 2.70 g of N-[1-(3,5-dimethoxyphenyl)ethyl]-N-[(4-fluorophenyl)-(3-nitrophenyl)methyl]amine [prepared as described in step (a) above], 3.13 g of nickel chloride hexahydrate and 1.00 g of sodium borohydride were reacted, to obtain 892 mg of isomer A and 546 mg of isomer B of the title compound as pale yellow oils, respectively.

Workup

  1. customa similar reaction, separation and purification procedure to
  2. customwere reacted

Sources & evidence

ORD record
ord-678c4d672f6445d3b497cbf176b469f0
Source dataset
uspto-grants-2001_12
Patent number
US06329405B1

Reaction notes

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